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Dr. Vito Valiante | Drucken |
vitovaliante

Vertretungsprofessor

Lehrstuhl für Allgemeine Mikrobiologie und Mikrobengenetik

Institut für Mikrobiologie
Biologisch-Pharmazeutische Fakultät
Friedrich-Schiller-Universität Jena
Neugasse 24
07743 Jena, Deutschland

Telefon: +49 3641 532-1090
Fax: +49 3641 532-2090
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Forschungsschwerpunkte

  • Synthetische Biologie
  • Molekulare und funktionelle Genetik
  • Identifizierung und Expression von stillen Genclustern für Sekundärmetabolite
  • Regulation von Sekundärmetaboliten
  • Zellfreie Biosynthese-Systeme

Wissenschaftlicher Werdegang

2015                Nachwuchsgruppenleiter Biobricks mikrobieller Naturstoffsynthasen am Leibniz-Institut für Naturstoff-Forschung

und Infektionsbiologie – Hans-Knöll-Institut (HKI), Jena

2012 – 2015     Wissenschaftlicher Mitarbeiter und Projektleiter, Abteilung für Molekulare und Angewandte Mikrobiologie, HKI, Jena

2006 – 2012     Postdoktorand, Abteilung für Molekulare und Angewandte Mikrobiologie, HKI, Jena

2006                Dr. rer. nat. in Biotechnologie, Universität „Federico II“, Neapel, Italien

2004-2006        Gaststudent an der Universität Durham, Durham, UK

2002                Studium Biotechnologie, Diplom in Biotechnologie an der Universität „Federico II“, Neapel, Italien

Bedeutende Preise, Ämter und Funktionen

seit Mai 2017   JSMC Fakultätsmitglied

seit 2017          Review Editor, Frontiers in Cellular Microbiology

seit 2016          Editor, Fungal Biology

seit 2014          Review Editor, Frontiers in Microbiology

2014                medac-Forschungspreis

03/2009            Fortgeschrittenenschulung „Sicherheitsaspekte der Gentechnik § 15 GenTSV“

Geförderte Projekte

7. Forschungsrahmenprogramm der Europäischen Union
Marie Curie Reintegration Grant CELLWALLPATH
Laufzeit:           09/2009 – 09/2012

7. Forschungsrahmenprogramm der Europäischen Union
ERA-NET Pathogenomics
ANTIFUN “The Cell Wall as a Target to Improve Antifungal Therapy against Aspergillosis,” by BFU2008-04709-E/BMC (German Federal Ministry of Education and Research: BMBF FKZ 0315439)
Laufzeit:           09/2009 – 09/2012

Publikationen

(*Gemeinsame Erstautorenschaft, #Corresponding author)

Manfiolli, A. O., de Castro, P. A., Dos Reis, T. F., Dolan, S., Doyle, S., Jones, G., Riano Pachon, D. M., Ulas, M., Noble, L. M., Mattern, D. J., Brakhage, A. A., Valiante, V., Silva-Rocha, R., Bayram, O., and Goldman, G. H. (2017) Aspergillus fumigatus protein phosphatase PpzA is involved in iron assimilation, secondary metabolite production, and virulence, Cell Microbiol [Epub ahead of print]

Valiante, V.*, Mattern, D. J., Schuffler, A., Horn, F., Walther, G., Scherlach, K., Petzke, L., Dickhaut, J., Guthke, R., Hertweck, C., Nett, M., Thines, E., and Brakhage, A. A. (2017) Discovery of an Extended Austinoid Biosynthetic Pathway in Aspergillus calidoustus, ACS Chem Biol 12, 1227-1234.

Weber, J., Valiante, V., Nodvig, C. S., Mattern, D. J., Slotkowski, R. A., Mortensen, U. H., and Brakhage, A. A. (2017) Functional Reconstitution of a Fungal Natural Product Gene Cluster by Advanced Genome Editing, ACS Synth Biol 6, 62-68.

Macheleidt, J., Mattern, D. J., Fischer, J., Netzker, T., Weber, J., Schroeckh, V., Valiante, V., and Brakhage, A. A. (2016) Regulation and Role of Fungal Secondary Metabolites, Annu Rev Genet 50, 371-392.

Valiante, V.*, Baldin, C., Hortschansky, P., Jain, R., Thywissen, A., Strassburger, M., Shelest, E., Heinekamp, T., and Brakhage, A. A. (2016) The Aspergillus fumigatus conidial melanin production is regulated by the bifunctional bHLH DevR and MADS-box RlmA transcription factors, Mol Microbiol 102, 321-335.

Horn, F., Linde, J., Mattern, D. J., Walther, G., Guthke, R., Scherlach, K., Martin, K., Brakhage, A. A., Petzke, L., and Valiante, V.# (2016) Draft Genome Sequences of Fungus Aspergillus calidoustus, Genome Announc 4.

Bruder Nascimento, A. C., Dos Reis, T. F., de Castro, P. A., Hori, J. I., Bom, V. L., de Assis, L. J., Ramalho, L. N., Rocha, M. C., Malavazi, I., Brown, N. A., Valiante, V., Brakhage, A. A., Hagiwara, D., and Goldman, G. H. (2016) Mitogen activated protein kinases SakA(HOG1) and MpkC collaborate for Aspergillus fumigatus virulence, Mol Microbiol 100, 841-859.

Altwasser, R., Baldin, C., Weber, J., Guthke, R., Kniemeyer, O., Brakhage, A. A., Linde, J., and Valiante, V.# (2015) Network Modeling Reveals Cross Talk of MAP Kinases during Adaptation to Caspofungin Stress in Aspergillus fumigatus, PLoS One 10, e0136932.

Horn, F., Linde, J., Mattern, D. J., Walther, G., Guthke, R., Brakhage, A. A., and Valiante, V.# (2015) Draft Genome Sequence of the Fungus Penicillium brasilianum MG11, Genome Announc 3.

Mattern, D. J., Valiante, V., Unkles, S. E., and Brakhage, A. A. (2015) Synthetic biology of fungal natural products, Front Microbiol 6, 775.

Mattern, D. J., Schoeler, H., Weber, J., Novohradska, S., Kraibooj, K., Dahse, H. M., Hillmann, F., Valiante, V., Figge, M. T., and Brakhage, A. A. (2015) Identification of the antiphagocytic trypacidin gene cluster in the human-pathogenic fungus Aspergillus fumigatus, Appl Microbiol Biotechnol 99, 10151-10161.

Valiante, V.*, Monteiro, M. C., Martin, J., Altwasser, R., El Aouad, N., Gonzalez, I., Kniemeyer, O., Mellado, E., Palomo, S., de Pedro, N., Perez-Victoria, I., Tormo, J. R., Vicente, F., Reyes, F., Genilloud, O., and Brakhage, A. A. (2015) Hitting the caspofungin salvage pathway of human-pathogenic fungi with the novel lasso peptide humidimycin (MDN-0010), Antimicrob Agents Chemother 59, 5145-5153.

Netzker, T., Fischer, J., Weber, J., Mattern, D. J., Konig, C. C., Valiante, V., Schroeckh, V., and Brakhage, A. A. (2015) Microbial communication leading to the activation of silent fungal secondary metabolite gene clusters, Front Microbiol 6, 299.

Valiante, V.#, Macheleidt, J., Foge, M., and Brakhage, A. A. (2015) The Aspergillus fumigatus cell wall integrity signaling pathway: drug target, compensatory pathways, and virulence, Front Microbiol 6, 325.

Baldin, C., Valiante, V.*#, Kruger, T., Schafferer, L., Haas, H., Kniemeyer, O., and Brakhage, A. A. (2015) Comparative proteomics of a tor inducible Aspergillus fumigatus mutant reveals involvement of the Tor kinase in iron regulation, Proteomics 15, 2230-2243.

Schwartze, V. U., Winter, S., Shelest, E., Marcet-Houben, M., Horn, F., Wehner, S., Linde, J., Valiante, V., Sammeth, M., Riege, K., Nowrousian, M., Kaerger, K., Jacobsen, I. D., Marz, M., Brakhage, A. A., Gabaldon, T., Bocker, S., and Voigt, K. (2014) Gene expansion shapes genome architecture in the human pathogen Lichtheimia corymbifera: an evolutionary genomics analysis in the ancient terrestrial mucorales (Mucoromycotina), PLoS Genet 10, e1004496.

Unkles, S. E., Valiante, V.*, Mattern, D. J., and Brakhage, A. A. (2014) Synthetic biology tools for bioprospecting of natural products in eukaryotes, Chem Biol 21, 502-508.

Heinekamp, T., Thywissen, A., Macheleidt, J., Keller, S., Valiante, V., and Brakhage, A. A. (2012) Aspergillus fumigatus melanins: interference with the host endocytosis pathway and impact on virulence, Front Microbiol 3, 440.

Müller, S., Baldin, C., Groth, M., Guthke, R., Kniemeyer, O., Brakhage, A. A., and Valiante, V#. (2012) Comparison of transcriptome technologies in the pathogenic fungus Aspergillus fumigatus reveals novel insights into the genome and MpkA dependent gene expression, BMC Genomics 13, 519.

Horn, F., Heinekamp, T., Kniemeyer, O., Pollmacher, J., Valiante, V., and Brakhage, A. A. (2012) Systems biology of fungal infection, Front Microbiol 3, 108.

Monteiro, M. C., de la Cruz, M., Cantizani, J., Moreno, C., Tormo, J. R., Mellado, E., De Lucas, J. R., Asensio, F., Valiante, V., Brakhage, A. A., Latge, J. P., Genilloud, O., and Vicente, F. (2012) A new approach to drug discovery: high-throughput screening of microbial natural extracts against Aspergillus fumigatus using resazurin, J Biomol Screen 17, 542-549.

Jain, R., Valiante, V., Remme, N., Docimo, T., Heinekamp, T., Hertweck, C., Gershenzon, J., Haas, H., and Brakhage, A. A. (2011) The MAP kinase MpkA controls cell wall integrity, oxidative stress response, gliotoxin production and iron adaptation in Aspergillus fumigatus, Mol Microbiol 82, 39-53.

Valiante, V., Jain, R., Heinekamp, T., and Brakhage, A. A. (2009) The MpkA MAP kinase module regulates cell wall integrity signaling and pyomelanin formation in Aspergillus fumigatus, Fungal Genet Biol 46, 909-918.

Rispail, N., Soanes, D. M., Ant, C., Czajkowski, R., Grunler, A., Huguet, R., Perez-Nadales, E., Poli, A., Sartorel, E., Valiante, V., Yang, M., Beffa, R., Brakhage, A. A., Gow, N. A., Kahmann, R., Lebrun, M. H., Lenasi, H., Perez-Martin, J., Talbot, N. J., Wendland, J., and Di Pietro, A. (2009) Comparative genomics of MAP kinase and calcium-calcineurin signalling components in plant and human pathogenic fungi, Fungal Genet Biol 46, 287-298.

Valiante, V., Heinekamp, T., Jain, R., Hartl, A., and Brakhage, A. A. (2008) The mitogen-activated protein kinase MpkA of Aspergillus fumigatus regulates cell wall signaling and oxidative stress response, Fungal Genet Biol 45, 618-627.

 

Buchkapitel

Horn, F., Valiante, V., Guthke, R., Brakhage, A. A. (2014) Data-driven systems biology of fungal infections. In: Sullivan D, Moran GP (eds.) Human pathogenic Fungi: Molecular biology and pathogenic mechanisms Caister Academic Press, Norfolk, U.K.. ISBN: 978-1-908230-44.

Heinekamp, T., Valiante, V., Koester-Eiserfunke, N., Brakhage, A. A. (2014) Functional genomics to characterize opportunistic pathogens. In: Nowrousian M (ed.) The Mycota 13, pp. 321-347. Springer. ISBN: 9783642452178.